O-(2-[18F]氟乙基)-5-羟基-L-色氨酸(5-18FEHTP)的合成动物体内分布及MicroPET显像 |
| |
引用本文: | 李瑞芬.O-(2-[18F]氟乙基)-5-羟基-L-色氨酸(5-18FEHTP)的合成动物体内分布及MicroPET显像[J].同位素,2009,22(2):0. |
| |
作者姓名: | 李瑞芬 |
| |
作者单位: | 中国医学科学院 中国协和医科大学 北京协和医院 核医学科 |
| |
摘 要: | 通过对现有CTI公司计算机控制的化学合成模块(CPCU) 进行改造,首次合成了L-5-羟基色氨酸类似物(5-18FEHTP),并用高效液相(HPLC) 检测其放化纯度,所得的产品用于昆明小鼠的S180肉瘤模型显像。结果显示,采用改进方法合成5-18FEHTP的总时间是45min,纯化时间是20min,放化收率为12-16%(n=15),产品的放化纯度大于98%。MicroPET显像结果表明,5-18FEHTP在S180肉瘤浓集程度明显高于周围其它组织。以上结果提示利用CPCU半自动合成5-18FEHTP,方法简便、稳定、产品纯度较高。动物生物分布和显像结果表明5-18FEHTP可能成为一种新的PET显像剂。
|
关 键 词: | 合成 O-(2-[18F] 氟乙基)-5-羟基-L-色氨酸(5-18FEHTP) Micro PET 显像 |
收稿时间: | 2009-02-19 |
Synthesis, biodistribution of animal and MicroPET Imaging of O-(2-[18F]fluoroethyl)-5-hydroxy-L-try- ptophan (5-18FEHTP) |
| |
Abstract: | 5-18FEHTP was synthesized by using a modified chemistry process control unit (CPCU). Radiochemical purity was over 98% measured by High Performance Liquid Chromatograph (HPLC). After injecting of 5-18FEHTP through tail vein, the mice was scanned with Micro PET. The no decay corrected radiochemical yield of 5-18FEHTP was 12-16% (n=15) within 45min total reaction time, and the manually purified time was about 20min. 5-18FEHTP can be conveniently synthesized with modified CPCU and the labeling yield was stable, the results of Micro PET imaging indicated that 5-18FEHTP may be a new promising PET tracer. |
| |
Keywords: | synthesis O-(2-[18F] fluoroethyl)-5-Hydroxy-L-tryptophan (5-18FEHTP) Micro PET imaging |
|
| 点击此处可从《同位素》浏览原始摘要信息 |
|
点击此处可从《同位素》下载全文 |