加兰他敏制备方法研究进展

介绍了一种胆碱酯酶抑制剂——加兰他敏的特性和药用价值。概述了加兰他敏从黄水仙、沃氏雪花莲中提取、石蒜中提取及逆流色谱法精制、喇叭水仙酶法中提取的方法、工艺;以3,4-二甲氧基苯甲醛、3,4,5-三羟基苯甲酸甲酯和异香草醛和酪胺为起始原料合成加兰他敏的方法。认为目前工业化大规模生产尚存在问题,应运用生物技术手段,开发高产加兰他敏的石蒜品种,同时开展大规模种植;简化合成生产工艺、降低成本。

Advances in Researches on Preparing Methods of Galanthamine

The characteristics and medicinal values of galanthamine,a cholinesterase inhibitor,were introduced. Some preparation methods of galanthanime including extraction and organic synthesis were summarized,such as extraction from narcissus,galanthus woronawii losink,and lycoris radiate and countereurrent chromatography refining,and enzymatic extraction from hyacinths orientalis,as well as the organic synthesis using 3,4-dimethoxybenzaldehyde,methyl 3,4,5-trihydroxybenzoate,isovanilin and tyramine as raw materials. Problems still exist for large-scale industrial production presently,new type of amaryllidaceae with high production capability of galanthamine should be developed and planted in large scale,biologic technology should also be applied to simplify the synthetic process and reduce cost.