| 3-溴哒嗪的合成 |
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| 引用本文： | 洪东风,张海祥,张俊才.3-溴哒嗪的合成[J].陕西化工,2012(9):1645-1647. |
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| 作者姓名： | 洪东风 张海祥 张俊才 |
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| 作者单位： | [1]洛阳师范学院化学化工学院,河南洛阳471022 [2]陕西阿俾拔致生物科技有限公司,陕西西安710075 |
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| 基金项目： | 西安市科技创新基金（CX08063） |
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| 摘 要： | 以3,6-二氯哒嗪为原料,与15%NaOH在100℃反应6 h,生成3-氯-6-羟基哒嗪,在碳钯的催化作用下脱氯,生成3-羟基哒嗪,与三溴氧磷在80℃反应25 min,生成3-溴哒嗪,摩尔总收率达61.2%。
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| 关 键 词： | 哒嗪 3-溴哒嗪 合成 收率 |
Synthesis of 3-bromopyridazine |
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| HONG Dong-feng,ZHANG Hai-xiang,ZHANG Jun-cai.Synthesis of 3-bromopyridazine[J].Applied Chemical Industry,2012(9):1645-1647. |
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| Authors: | HONG Dong-feng ZHANG Hai-xiang ZHANG Jun-cai |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang 471022, China; 2. Shaanxi A-Big-Bridge Biology Sci-Tech Co., Ltd., Xi＇ an 710075, China) |
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| Abstract: | 3,6-Dichloropyridazine as raw material first reacts with 15% NaOH at 100 ℃ at 6 h to produce 3-chloro-6-hydroxypyridazine which is dechlorinated to produce 3-hydroxypyridazine catalyzed by carbon palladium. The product reacts with POBr3 for 25 min at 80 ℃ to generate 3-bromopyridazine. The mole ra- tio of total yield reaches 61.2%. |
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| Keywords: | pyridazine 3-bromopyridazine synthesis yield |
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