Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases |
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| Authors: | Yolanda Diz-Chaves,Zainab Mastoor,Carlos Spuch,Lucas C. Gonzá lez-Matí as,Federico Mallo |
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| Affiliation: | 1.Biomedical Research Centre (CINBIO), University of Vigo, Galicia Sur Health Research Institute, 36310 Vigo, Spain;2.Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain |
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| Abstract: | The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies. |
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| Keywords: | GLP-1, GLP-1 RAS, GLP-1R, brain inflammation, multiple sclerosis, ALS, Alzheimer’ s disease, Parkinson’ s disease, microglia, astrocytes |
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