Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels |
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Authors: | Benbo Zhao Mingda Zhao Liming Li Shixiong Sun Heping Yu Yuan Cheng Yuedi Yang Yujiang Fan Yong Sun |
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Affiliation: | 1.School of Chemical Engineering and Technology, North University of China, Taiyuan 030051, China;2.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China;3.Dezhou Graduate School, North University of China, Dezhou 253034, China;4.Guangdong Provincial Key Laboratory of Natural Rubber Processing, Agricultural Products Processing Research Institute, Chinese Academy of Tropical Sciences, Zhanjiang 524001, China |
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Abstract: | Natural polymer hydrogels have good mechanical properties and biocompatibility. This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels. Hyaluronic acid (HA) and gelatin (Gel) were modified with methacrylate anhydride. The catechin group was further introduced into the HA chain inspired by the adhesion chemistry of marine mussels. Hence, the double-crosslinked hydrogel (HG) was formed by the photo-crosslinking of double bonds and the oxidative-crosslinking of catechins. Moreover, hydroxyapatite was introduced into HG to form hydroxyapatite-enhanced hydrogels (HGH). The results indicate that, with an increase in crosslinking network density, the stiffness of hydrogels became higher; these hydrogels have more of a compact pore structure, their anti-degradation property is improved, and swelling property is reduced. The introduction of hydroxyapatite greatly improved the mechanical properties of hydrogels, but there is no change in the stability and crosslinking network structure of hydrogels. These inorganic phase-enhanced hydrogels were expected to be applied to tissue engineering scaffolds. |
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Keywords: | hyaluronic acid gelatin dopamine double crosslinked hydroxyapatite-enhanced hydrogel |
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