Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging |
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| Authors: | Hyun Jung Hwang Nayeon Kim Allison B. Herman Myriam Gorospe Jae-Seon Lee |
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| Affiliation: | 1.Research Center for Controlling Intercellular Communication, College of Medicine, Inha University, Incheon 22212, Korea;2.Department of Molecular Medicine, College of Medicine, Inha University, Incheon 22212, Korea;3.Program in Biomedical Science and Engineering, College of Medicine, Inha University, Incheon 22212, Korea;4.Laboratory of Genetics and Genomics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA |
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| Abstract: | Aging causes a progressive decline in the structure and function of organs. With advancing age, an accumulation of senescent endothelial cells (ECs) contributes to the risk of developing vascular dysfunction and cardiovascular diseases, including hypertension, diabetes, atherosclerosis, and neurodegeneration. Senescent ECs undergo phenotypic changes that alter the pattern of expressed proteins, as well as their morphologies and functions, and have been linked to vascular impairments, such as aortic stiffness, enhanced inflammation, and dysregulated vascular tone. Numerous molecules and pathways, including sirtuins, Klotho, RAAS, IGFBP, NRF2, and mTOR, have been implicated in promoting EC senescence. This review summarizes the molecular players and signaling pathways driving EC senescence and identifies targets with possible therapeutic value in age-related vascular diseases. |
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| Keywords: | cellular senescence endothelial cell molecular player signaling pathway putative target age-related vascular disease |
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