Two new naphthoquinones with antiviral activity from Rhinacanthus nasutus |
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| Authors: | A Sendl JL Chen SD Jolad C Stoddart E Rozhon M Kernan W Nanakorn M Balick |
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| Affiliation: | Shaman Pharmaceuticals, South San Francisco, California 94080, USA. |
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| Abstract: | Two new naphthoquinones, rhinacanthin-C (1) and rhinacanthin-D (2), exhibit inhibitory activity against cytomegalovirus (CMV), with EC50 values of 0.02 and 0.22 microgram/mL, respectively, against human CMV. They were isolated from the medicinal plant Rhinacanthus nasutus (Acanthaceae). The structures of the compounds were determined by analysis of their spectroscopic data, in particular, 2D NMR. |
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