| 对羟基苯甲酸丙酯的合成条件 |
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| 引用本文： | 张相年,赵树进,赖雅平,孙冠穗. 对羟基苯甲酸丙酯的合成条件[J]. 中国食品添加剂, 2005, 0(6): 57-59 |
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| 作者姓名： | 张相年 赵树进 赖雅平 孙冠穗 |
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| 作者单位： | 1. 广州军区广州总医院药学部,广州,510010
2. 广州大学生化学院轻化系,广州,510091 |
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| 摘 要： | 目的:制备对羟基苯甲酸丙酯。方法:用高效液相色谱跟踪反应进程,考察用不同浓度的强酸性阳离子交换树脂和对甲苯磺酸作催化剂、对比用与不用无水硫酸镁作吸水剂以及不同的反应时间对合成反应速度的影响。结果:对甲苯磺酸催化效果远优于阳离子交换树脂。以1%的对甲苯磺酸催化、无水硫酸镁作吸水剂以及反应6小时是制备对羟基苯甲酸丙酯的优化工艺条件,终产品收率达87%。
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| 关 键 词： | 对羟基苯甲酸丙酯 制备 合成 |
| 文章编号： | 1006-2513(2005)06-0057-03 |
| 收稿时间： | 2005-07-11 |
| 修稿时间： | 2005-07-11 |
The conditions for preparation of propyl p-hydroxybenzoate |
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| ZHANG Xiang-nian,ZHAO Shu-jin,LAI Ya-ping,SHUN Guan-shui. The conditions for preparation of propyl p-hydroxybenzoate[J]. China Food Additives, 2005, 0(6): 57-59 |
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| Authors: | ZHANG Xiang-nian ZHAO Shu-jin LAI Ya-ping SHUN Guan-shui |
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| Affiliation: | 1.Pharmaceutical Department of Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010;2.Light Chemical Engineering Department of Guangzhou Biology and Chemistry College of Guangzhou University, Guangzhou, 510091 |
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| Abstract: | Aim:to prepare propyl p-hydroxybenzoate.Methods:The preparation reaction were studied including different catalysis(ion resin and p-methylbenzoic acid),different catalysis amount,and MgSO_(4)as a water absorbent to optimize synthesis conditions,HPLC were applied to detect reaction progress.Result:p-methylbenzoic acid was much better catalyst than ion resin during preparation.The best conditions for preparing propyl p-hydroxybenzoate were 1% p-methylbenoic acid as a catalyst,MgSO_(4)as a water absorbent,and 6 hours reaction time.The yield was 87% based on the p-hydroxybenzoic acid. |
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| Keywords: | propyl p-hydroxybenzoate preparation synthesis |
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