Implementation of substrates for surface-enhanced Raman spectroscopy for continuous analysis in an optofluidic device |
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Authors: | Wilhelm Hüttner Konstantin Christou Alexander G?hmann Volker Beushausen Hainer Wackerbarth |
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Affiliation: | 1. Laser-Laboratorium G?ttingen, Hans-Adolf-Krebs-Weg 1, 37077, G?ttingen, Germany
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Abstract: | The fabrication of substrates for surface-enhanced Raman spectroscopy (SERS), which offer high enhancement factors as well as spatially homogeneous distribution of the enhancement, plays an important role for expanding the surface-enhanced Raman spectroscopy to a powerful quantitative and non-invasive measurement technique. In this paper, a method for the fabrication of capable SERS-active substrates by laser treatment of gold films supported on glass with single 351?nm UV-laser pulses is presented. Resulting nanometer scaled structures show enhancement factors of up to 106 with very high spatial reproducibility for a monolayer of benzenethiol. A method for integration of these substrates into PDMS microchannels is shown. A technique for the generation of a simple mold master for PDMS replication is presented. Rhodamine 6G is used as model system to demonstrate continuous measurements on a solid SERS-active substrate in a microchannel. The label-free detection of the biological molecule albumin is improved by an order of magnitude. |
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