槲皮苷和山奈酚对糖尿病小鼠血糖及血脂水平的影响

本研究对黄酮单体山奈酚、槲皮苷对糖尿病小鼠降血糖、血脂效果进行试验,建立了小鼠实验模型,经喂养后测定结果表明,黄酮单体山奈酚、槲皮苷能够有效的降低小鼠的血糖BG、TG、TC和MDA水平,对增加血清SOD、GSH-Px活性也有明显促进作用,其中以10 mg/kg.bw.d为最佳剂量。这表明黄酮单体山奈酚、槲皮苷对糖尿病防治有明显作用。

Effect of Kaempferol and Quercetin on Blood Sugar and Fat Contents of Diabetic Model Mice

The Anti-hypoglycemic effect of kaempferol and quercetin on diabetic model mice were studied. Two groups of diabetic model mice induced by alloxan were fed respectively with 2 doses of kaempferol and quercetin for 18 d. A group of non-model mice and a group of model mice fed with the same volume water were taken as the controls, and a group of model mice fed with Xiao ke wan (a Chinese medicine for diabete) was taken as the positive control. Then levels of serum glucose, TG, TC, MDA, and SOD and GSH-Px activities were investigated. The results showed that by kaempferol and quercetin, levels of serum glucose, TG, TC and MDA were significantly reduced, and SOD and GSH-Px activities were apparently enhanced. Among 2 doses of kaempferol and quercetin, 10 mg/kg bw?d was the modest one.