Determination of peptidoglycan-associated protein in Escherichia coli NCIB 8545 by capillary zone electrophoresis |
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Authors: | JZ Xing RM Richards |
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Affiliation: | School of Pharmacy, Robert Gordon University, Schoolhill, Aberdeen, UK. |
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Abstract: | An efficient reliable and sensitive capillary zone electrophoresis assay for the six major bacterial peptidoglycan-associated proteins of Escherichia coli NCIB 8545 is described. The method provides the facility to determine quantitatively the effect of antibacterials on bacterial peptidoglycan-associated protein synthesis and thus to further elucidate the mechanism of antibacterial action of such drugs as the antifolates which recently have been shown to adversely affect peptidoglycan synthesis. |
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