| 清热化痰合剂质量标准的研究 |
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| 引用本文： | 亓淑芬,张乐青,丁健,葛朝晖. 清热化痰合剂质量标准的研究[J]. 食品与药品, 2021, 0(1): 40-43 |
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| 作者姓名： | 亓淑芬 张乐青 丁健 葛朝晖 |
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| 作者单位： | 阳谷县人民医院;阳谷县市场监管稽查大队;临沂大学 |
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| 摘 要： | 目的 制定清热化痰合剂的质量标准.方法 采用薄层色谱法(TLC)定性鉴别方中的麻黄和浙贝母.采用高效液相色谱法(HPLC)测定绿原酸的含量,色谱柱为Unitary C18(250 mm×4.6 mm,5μm);流动相为0.1％醋酸溶液-乙腈,梯度洗脱;流速1 ml/min,进样量10μl,柱温30℃,检测波长为327 ...
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| 关 键 词： | 清热化痰合剂 高效液相色谱法 薄层色谱法 质量标准 |
Quality Control of Qingre Huatan Mixture |
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| QI Shu-fen,ZHANG Le-qing,DING Jian,GE Zhao-hui. Quality Control of Qingre Huatan Mixture[J]. Food and Drug, 2021, 0(1): 40-43 |
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| Authors: | QI Shu-fen ZHANG Le-qing DING Jian GE Zhao-hui |
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| Affiliation: | (People's Hospital of Yanggu,Yanggu 252300,China;Market Supervision Inspection Team of Yanggu,Yanggu 252300,China;Linyi University,Linyi 252000,China) |
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| Abstract: | Objective To establish the quality standard of Qingre Huatan Mixture.Methods TLC identification of Ephedrea herba and Fritillariae thunbergii bulbus was performed.Chlorogenic acid was determined by HPLC with gradient elution.The analysis was performed on Unitary C18 column(250 mm×4.6 mm,5μm)with 0.1%acetic acidacetonitrile as mobile phase.The detection wave length was 327 nm.The column temperature was 30℃.Results The TLC identification method for two kinds of Chinese medicinal herbs was highly specific,and the negative control was of no interference.The linear range of chlorogenic acid was 20-100μg(r=0.9980)and the average recovery of chlorogenic acid was 98.06%,with RSD of 1.16%.Conclusion The method is simple and highly accurate,and can be used for the quality control of Qingre Huatan Mixture. |
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| Keywords: | Qingre Huatan Mixture HPLC TLC quality standard |
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