Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats |
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| Authors: | Byoung-Ok Cho Hyung-Won Ryu Yangkang So Chang-Hyun Jin Ji-Yeong Baek Ki-Hun Park Eui-Hong Byun Il-Yun Jeong |
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| Affiliation: | 1. Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Republic of Korea;2. Division of Applied Life Science (BK21 Program), IALS, Graduate School of Gyeongsang National University, Jinju 660-701, Republic of Korea;3. Department of Microbiology and Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea |
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| Abstract: | The aim of this study was to investigate the protective effect of 2,3-dehydrosilybin (DHS) against carbon tetrachloride (CCl4)-induced liver injury in rats. Administration of DHS significantly attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in CCl4-treated rats. Moreover, we showed that DHS prevented DNA damage and decreased the protein levels of γ-H2AX, which is a specific DNA damage marker, in CCl4-treated rat livers. DHS also markedly increased the activity of antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in CCl4-treated rat livers. Furthermore, we found that DHS significantly inhibited the production of serum nitric oxide as well as the levels of serum IL-6, IFN-γ, and TNF-α in CCl4-treated rats. Additionally, DHS significantly suppressed iNOS expression on the protein levels in CCl4-treated rat livers. Collectively, the present study suggests that DHS protects the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms. |
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| Keywords: | 2,3-Dehydrosilybin Carbon tetrachloride Liver injury Antioxidant enzyme Lipid peroxidation Anti-inflammation |
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