Comparative analyses of seeds of wild fruits of Rubus and Sambucus species from Southern Italy: Fatty acid composition of the oil,total phenolic content,antioxidant and anti-inflammatory properties of the methanolic extracts |
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Authors: | Alessia Fazio Pierluigi Plastina Jocelijn Meijerink Renger F Witkamp Bartolo Gabriele |
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Affiliation: | 1. Department of Pharmaceutical Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy;2. Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, Netherlands |
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Abstract: | Fruit seeds are byproducts from fruit processing. Characterisation of the bioactive compounds present in seeds and evaluation of their potential biological properties is therefore of particular importance in view of a possible valorisation of seeds as a source of health beneficial components. In this work, we have analysed the seeds of Sambucus and Rubus species in order to identify their bioactive components and to determine the antioxidant and anti-inflammatory activities of the extracts. We first analysed their oil content, in order to assess the fatty acid profile and tocopherol content. Moreover, the methanolic extracts of the seeds were analysed for their total phenolic contents and antioxidant capacities. Polyphenols were identified by HPLC–ESI–MS/MS analysis. Furthermore, extracts were evaluated for their inhibitory effects on the production of LPS-induced inflammatory mediators (NO, CCL-20) in RAW 264.7 cells. |
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Keywords: | Rubus and Sambucus fruit seeds Fatty acid profile Tocopherol composition DPPH radical scavenging activity Total phenolic content Ellagic acid content Anti-inflammatory Nitric oxide CCL20 |
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