| 全身麻醉药物遗传药理学研究进展 |
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| 引用本文： | 谢商宸,李 玮,廖 萍,贺毅憬,Howard L. Mcleod.全身麻醉药物遗传药理学研究进展[J].金属学报,2018,23(2):217-222. |
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| 作者姓名： | 谢商宸 李 玮 廖 萍 贺毅憬 Howard L. Mcleod |
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| 作者单位： | 1.中南大学湘雅医院临床药理研究所，长沙 410008，湖南;2.中南大学临床药理研究所,遗传药理学湖南省重点实验室，长沙 410078，湖南 |
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| 基金项目： | 国家自然科学基金（81403022，81673517，81773821） |
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| 摘 要： | 全身麻醉是指由多种全身麻醉药物引起的一系列无意识、记忆缺失、痛觉缺失、运动不能等状态。随着遗传药理学及药物基因组学的发展，全身麻醉中各类药物与自身遗传因素的关系越来越受到关注。本文对全身麻醉中常用的镇痛药、镇静催眠药、肌松药及止吐药的遗传药理学研究进行综述，归纳近年来的研究进展。
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| 关 键 词： | 全身麻醉 遗传药理学 药物基因组学 |
| 收稿时间： | 2017-11-07 |
| 修稿时间： | 2018-01-05 |
Research progress of general anesthesia in the pharmacogenetics |
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| XIE Shangchen,LI Wei,LIAO Ping,HE Yijing,MCLEOD Howard L..Research progress of general anesthesia in the pharmacogenetics[J].Acta Metallurgica Sinica,2018,23(2):217-222. |
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| Authors: | XIE Shangchen LI Wei LIAO Ping HE Yijing MCLEOD Howard L |
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| Affiliation: | 1. Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China;2. Institute of Clinical Pharmacology Central South University,Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, Hunan, China |
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| Abstract: | General anesthesia is a state of unconsciousness, amnesia, analgesia and akinesia induced by drugs used in general anesthesia. Along with the development of pharmacogenetics and pharmacogenomics, pharmacogenetic studies of these drugs have been carried out continuously. This review summarizes the pharmacogenetics of commonly used general anesthesia drugs like analgesics, sedative-hypnotics, neuromuscular blockers and antiemetics in recent years. |
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| Keywords: | general anesthesia pharmacogenetics pharmacogenomics |
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