中药水疗联合茵栀黄口服液对新生儿黄疸的临床疗效

目的: 观察中药水疗联合茵栀黄口服液对新生儿黄疸的治疗效果。方法: 新生儿黄疸患者392例,随机分为观察组和对照组,每组各196例,两组均服用茵栀黄口服液,观察组辅以中药水疗,对照组进行常规沐浴,对比两组治疗前后的黄疸指数、黄疸消退时间、体质量变化、总胆红素（TBIL）、谷丙转氨酶（ALT）、总胆汁酸（TBA）、C反应蛋白（CRP）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、免疫球蛋白（Ig）A、IgG与IgM水平及红细胞免疫功能变化。结果: 治疗后,中药水疗组患儿的黄疸指数低于沐浴组,且患儿的黄疸消退时间明显更短,患儿治疗后的体质量高于对照组,差异具有统计学意义（P<0.05）。治疗后中药水疗组患儿血清TBIL、ALT、TBA水平均低于沐浴组,差异具有统计学意义（P<0.05）。中药水疗组患儿的血清CRP、IL-6、IL-8水平均低于对照组,差异具有统计学意义（P<0.05）。中药水疗组治疗后的血浆IgA、IgG、IgM水平及红细胞C3b受体（RBC-C3bR）明显高于沐浴组,差异有统计学意义（P<0.05）。结论: 在茵栀黄口服液治疗的基础上辅以中药水疗,可以有效地改善新生儿黄疸情况,并有助于患儿免疫能力的提高,安全性高且简便易行。

Effects of medicated bath hydrotherapy combined with Yinzhihuang oral liquid on neonatal jaundice

AIM: To observe the therapeutic effect of medicated bath hydrotherapy combined with Yinzhihuang oral liquid on neonatal jaundice. METHODS: A total of 392 neonates with jaundice were selected from March 2016 to January 2018 in our hospital, which were randomly divided into hydrotherapy group and shower group, each with 196 cases. Both groups took Yinzhihuang oral liquid. The hydrotherapy group was supplemented with medicated bath hydrotherapy, and the shower group was given routine shower. The following indexes, including jaundice index, jaundice regression time, weight change, TBIL, ALT, TBA, CRP, IL-6, IL-8, IgA, IgG and IgM levels, and changes in red cell immune function were compared between these two groups. RESULTS:After treatment, the jaundice index of the medicated bath hydrotherapy group was lower than that of the shower group, and the regression time of the jaundice was significantly shorter, while the weight of the children after treatment was higher than that of the shower group with significant differences (P<0.05). After treatment, serum levels of TBIL, ALT, and TBA in the medicated bath hydrotherapy group were lower than those in the shower group, and the difference was statistically significant (P<0.05). The levels of serum CRP, IL-6, and IL-8 in the Chinese medicine hydrotherapy group were lower than those in the shower group, and the difference was significant (P<0.05). The plasma levels of IgA, IgG, IgM, and RBC-C3bR in the medicated bath hydrotherapy group were significantly higher than those in the shower group. The difference was statistically significant (P<0.05). CONCLUSION: The treatment of Yinzhihuang oral liquid supplemented with medicated bath hydrotherapy can effectively improve the neonatal jaundice and contribute to the improvement of children's immunity.