IL-33/ST2在急性冠脉综合征中的研究进展

白介素-33(interleukin33, IL-33)是IL-1免疫球蛋白家族的新成员，可与靶细胞膜上的生长刺激表达基因2蛋白（ST2）结合形成跨膜复合体，形成IL-33/ST2信号通路，参与了与Th2活化相关的许多炎症和免疫疾病。近年来许多研究发现IL-33/ST2信号通路在冠心病等心脑血管疾病中也起到重要的作用。急性冠脉综合征是冠心病的一种严重类型，本质是冠状动脉炎性病变后，斑块的破裂和侵蚀过程。本文综述IL-33/ST2信号在急性冠脉综合征中研究进展，希望为急性冠脉综合征的治疗提供新的靶点和思路。

Research progress of IL33/ST2 in acute coronary syndrome

The interleukin-33 (IL-33), which is a new member of the Interleukin-1(IL-1) immunoglobulin family, binds to the target cell membrane growth-stimulating expression gene 2 (ST2) to form a trans membrane complex. The IL-33/ST2 signaling pathway is involved in many inflammatory and immune diseases with the activation of Th2. In recent years, many studies have reported that IL-33/ST2 signaling pathway also plays an important role in cardio- and cerebro-vascular diseases such as coronary heart disease. Acute coronary syndrome (ACS) is a serious type of coronary heart disease based on the process of plaque rupture and erosion following the inflammatory lesions of coronary artery. This article aims to provide a new target and idea for the treatment of acute coronary syndrome by reviewing the progress of the studies of IL-33/ST2 signaling in acute coronary syndrome.