| 伏立康唑的药效学研究评价 |
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| 引用本文： | 张,弨.伏立康唑的药效学研究评价[J].金属学报,2018,23(1):116. |
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| 作者姓名： | 张 弨 |
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| 作者单位： | 北京大学第三医院药剂科，北京 100191 |
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| 基金项目： | 国家自然科学基金（81403009） |
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| 摘 要： | 伏立康唑作为一线的抗真菌治疗药物，其临床应用越来越广泛。伏立康唑变异大，临床治疗过程中发现其药效学特征在不同人群有很大区别。本文围绕伏立康唑的药效学研究进行综述和评价，明确不同人群中影响药效学的因素，着重从临床疗效角度出发浅谈剂量调整的一般思路和对策。在特殊人群中，治疗药物监测结合药动学/药效学模型的仿真可以提高剂量调整的准确性。
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| 关 键 词： | 伏立康唑 侵袭性真菌感染 药效学 治疗药物监测 |
Pharmacodynamic studies evaluation of voriconazole |
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| ZHANG Chao.Pharmacodynamic studies evaluation of voriconazole[J].Acta Metallurgica Sinica,2018,23(1):116. |
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| Authors: | ZHANG Chao |
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| Affiliation: | Department of Pharmacy, Peking University Third Hospital, Beijing100191, China |
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| Abstract: | Voriconazole, as a first-line antifungal treatment, has been widely used in clinics. Significant variability of voriconazole has been found and its pharmacodynamic characteristics vary in different populations. In this paper, the review and evaluation of voriconazole pharmacodynamics are presented to indicate their determined influence factors according to populations and to investigate corresponding strategy of dosage adjustment. Therapeutic drug monitoring is suggested to combine with simulations through population pharmacokinetic/phamacodynamic model to improve the accuracy of dosage adjustment. |
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| Keywords: | voriconazole invasive fungal infection pharmacodynamics therapeutic drug monitoring |
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