A rare case of a thyrotropin-secreting pituitary tumor which responded to methimazole |
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Authors: | T Inukai Y Fujiwara Y Aso A Yamamoto Y Takemura |
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Affiliation: | Department of Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Japan. |
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Abstract: | A 52-year-old Japanese male complained of palpitations and excessive sweating. He showed evidence of hyperthyroidism, but without suppression of the serum thyroid-stimulating hormone (TSH). On admission, the serum level of the alpha-subunit of TSH was elevated, but tests for thyroid autoantibodies were negative. The TSH response to thyrotropin-releasing hormone (TRH) was blunted. Imaging studies revealed a pituitary tumor 2 cm in diameter. Administration of methimazole lowered the serum levels of thyroid hormones, and elevated the serum level of TSH. These findings led to the diagnosis of a thyrotropin-secreting pituitary tumor. Immunohistochemical analysis and electron microscopic findings verified the diagnosis. |
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