| 一种4-氮甾体激素化合物的合成 |
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| 引用本文： | 臧红霞.一种4-氮甾体激素化合物的合成[J].现代化工,2009,29(12). |
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| 作者姓名： | 臧红霞 |
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| 作者单位： | 邢台学院生物和化学系,河北,邢台054001 |
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| 摘 要： | 以孕甾双烯醇酮醋酸酯为起始原料,经次溴酸钠氧化、甲醇甲酯化得到3-羰基-4-雄甾烯-17-羧酸甲酯,再经Oppenauer氧化、双键的氧化切断、氨解环合、Δ~5双键加氢、酯氨解反应得酰胺类中间产物,然后碘化和脱碘反应进行1,2位脱氢合成非那甾胺.
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| 关 键 词： | 非那甾胺 N-叔丁基-3-羰基-4-氮杂-5-雄甾-17β-甲酰胺 合成 中间体 N-tert-butyl-3-oxo-4-aza-5-androst-17β-formamide |
Synthesis of a 4-azasteroid hormones compound |
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| ZANG Hong-xia.Synthesis of a 4-azasteroid hormones compound[J].Modern Chemical Industry,2009,29(12). |
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| Authors: | ZANG Hong-xia |
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| Abstract: | Pregnadienolone acetate is converted to 3-oxo-4-androstene-17-carboxylic methyl ester by hypobromous acid oxidation and ethanol esterification,then to give amide intermediates by Oppenauer oxidation,cleavage of Δ~4 double bond by oxidation,ring closure by ammonia,hydrogenation of Δ~5 double bond and ester ammonolysis.At last Finasteride is prepared by dehydrogenation of 1,2-position in A-ring with iodination and iodine removal. |
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| Keywords: | Finasteride synthesis intermediate |
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