镧对大鼠回避学习能力的影响

为了探讨氯化镧(LaCl3)染毒对子代大鼠回避学习记忆能力的影响。采用健康成年雌性Wistar大鼠24只,随机分为对照组(饮用蒸馏水);低剂量染镧组(饮用含0.25%LaCl3的蒸馏水溶液)、中剂量染镧组(饮用含0.5%LaCl3的蒸馏水溶液)和高剂量染镧组(饮用含1.0%LaCl3的蒸馏水溶液),每组6只动物。自雌鼠受孕日至仔鼠断乳后1个月以自由饮水的方式摄入镧。通过穿梭箱实验判断仔鼠的主被动逃避学习能力。结果显示,中剂量组仔鼠主动逃避潜伏期和电击次数显著高于低剂量组和对照组(P0.05),电击时间显著高于对照组(P0.05);高剂量组仔鼠主动逃避潜伏时间、电击次数和电击时间均显著高于中剂量组、低剂量组和对照组(P0.05)。LaCl3染毒造成大鼠主动逃避能力下降,LaCl3染毒组仔鼠表现出剂量依赖的回避学习能力损伤(P0.05)。

Effect of Lanthanum Chloride on Active Avoidance Learning Ability of Rats

The effect of lanthanum chloride( LaCl3) on active avoidance learning ability of rats was studied.Healthy adult female Wistar rats were randomly divided into four groups,including control group( fed with distilled water),low- dose group( fed with distilled water containing 0. 25% LaCl3),middle- dose group( fed with distilled water containing 0. 5% LaCl3) and high- dose group( fed with distilled water containing 1. 0% LaCl3). Female rats freely drank the water from the gestational day to the day a month after the newborm mice were weaned.The active avoidance learning ability was determined by the shuttle box test. The results show that shock number of newborn mice in middle- dose LaCl3 group were significantly more than that of mice in the control group and low-dose LaCl3group( P < 0. 05); the time and latency of active avoidance in shock stimulation of mice in middle-dose LaCl3 group were significantly longer than those of mice in the control group( P < 0. 05). the latency,shock number and time of mice in high- dose LaCl3 groups were significantly those of mice in control,low and middle dose LaCl3groups( P < 0. 05). It demonstrates that the active avoidance learning ability of rats was reduced by exposure to LaCl3. The active avoidance learning ability of rats in LaCl3- administrate groups shows a dose- dependent impairment( P < 0. 05).