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Gingival and dermal fibroblasts: their similarities and differences revealed from gene expression
Authors:Ebisawa Katsumi  Kato Ryuji  Okada Mai  Sugimura Tomotaka  Latif Mazlyzam Abdul  Hori Yusuke  Narita Yuji  Ueda Minoru  Honda Hiroyuki  Kagami Hideaki
Affiliation:Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.
Abstract:Gene expression profiles in normal human gingival and dermal fibroblasts were investigated using DNA microarrays. Their fundamental characteristics were almost identical, but 5% of their genes were uniquely expressed. These results help us to choose an optimal cell source for effective fibroblast-based cell therapy that is dependent on differential gene expression profiles.
Keywords:Fibroblast  Gingival tissue  Anti-aging  Microarray  Antioxidant
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