Liver lipid alterations in rats fed arginine deficient diets |
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Authors: | J A Milner E G Perkins |
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Affiliation: | (1) Department of Food Science, University of Illinois, 61801 Urbana, Illinois |
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Abstract: | Arginine deficiency is associated with a marked increase in liver lipids in the rat. Triglyceride accumulation accounts for
most of the fatty infiltration. Cholesterol concentration per gram of liver increased approximately 280% above control rats
receiving dietary arginine. The percentage of phospholipids was significantly decreased in the arginine-deficient rat liver
compared to controls. The fatty acid composition revealed a significant reduction in the percentage of palmitic, palmitoleic,
oleic, and linoleic acids. However, both stearic and arachidonic acids were increased approximately 250 and 160%, respectively,
in arginine-deficient livers compared to controls. Arginine deficiency in the rat causes a marked alteration in lipid metabolism
similar to that observed with orotic acid feeding. The similarities of arginine deficiency and orotic acid feeding are discussed. |
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