| 非水相细胞催化研究进展 |
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| 引用本文： | 侯丹丹,于炜婷,戴小敏,刘袖洞,马小军.非水相细胞催化研究进展[J].化工进展,2011,30(4):830-837. |
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| 作者姓名： | 侯丹丹 于炜婷 戴小敏 刘袖洞 马小军 |
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| 作者单位： | 1.大连大学环境与化学工程学院，辽宁 大连 116622；2中国科学院大连化学物理研究所，辽宁 大连 116023 |
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| 基金项目： | 国家重点基础研究发展计划，国家自然科学基金，"十一五"国家科技支撑计划，大连市青年科技人才基金 |
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| 摘 要： | 非水相细胞催化可提高水不溶化合物溶解度，改变热力学平衡以利于产物合成，是生物催化的重要组成部分。本文介绍了非水相细胞催化体系中溶剂和催化剂的筛选，如lgP值法和以产物高萃取率为目标的计算机辅助分子设计，以及催化剂的溶剂耐受性；综述了提高非水相细胞催化活性的方法，包括极端微生物的筛选和构建、细胞固定化等，以及非水相细胞催化反应在香料、药物及药物中间体等方面的应用现状；最后从生物学和工程学角度展望了非水相细胞催化研究的努力方向。
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| 关 键 词： | 非水相 细胞催化 细胞固定化 |
Progress of whole cell-based biocatalysis in nonaqueous media |
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| HOU Dandan,YU Weiting,DAI Xiaomin,LIU Xiudong,MA Xiaojun.Progress of whole cell-based biocatalysis in nonaqueous media[J].Chemical Industry and Engineering Progress,2011,30(4):830-837. |
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| Authors: | HOU Dandan YU Weiting DAI Xiaomin LIU Xiudong MA Xiaojun |
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| Affiliation: | 1School of Environment and Chemical Engineering，Dalian University，Dalian 116622，Liaoning，China；2Dalian Institute of Chemical Physics，Chinese Academy of Sciences，Dalian 116023，Liaoning，China |
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| Abstract: | Nonaqueous whole cell-based biocatalysis，as an important part of biocatalysis，which can enhance the solubility of poorly soluble compounds，change the thermodynamic equilibrium in favor of product synthesis and so on. In this paper，we introduce the selection of organic solvents and biocatalysts in nonaqueous whole cell biocatalysis system，such as lgP method，computer aided molecule design based on high product extractability，and solvent resistance of biocatalysts. Moreover，we review the methods to improve cell catalytic activity in nonaqueous media，including screening and construction of extreme microorganisms，cell immobilization，and recent application of nonaqueous whole cell-based biocatalysis in spices，drugs and medicine intermediates. Finally，we propose the main efforts on nonaqueous whole cell-based biocatalysis in view of biology and engineering. |
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