| 4-氨基-3,5-二氯-2,6-二氟吡啶的合成研究 |
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| 引用本文： | 杨剑波,庞怀林,黄超群,陶贤鉴.4-氨基-3,5-二氯-2,6-二氟吡啶的合成研究[J].精细化工中间体,2007,37(2):20-21. |
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| 作者姓名： | 杨剑波 庞怀林 黄超群 陶贤鉴 |
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| 作者单位： | 湖南化工研究院,湖南,长沙,410007 |
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| 摘 要： | 以3,5-二氯-2,4,6-三氟吡啶(TFP)为原料,水为溶剂,采用带压氨解合成氟草烟的中间体4-氨基-3,5-二氯-2,6-二氟吡啶,对反应条件进行了研究,优化反应条件为:反应温度80℃,反应时间30min,物料比n(TFP)∶n(氨水)=1∶3.5,苄基三乙基氯化铵的用量为TFP质量的5%。优化反应条件下收率为83.5%,产品含量为98.6%,其结构经红外分析、元素分析、核磁共振确证。
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| 关 键 词： | 3 5-二氯-2 4 6-三氟吡啶 氨化 4-氨基-3 5-二氯-2 6-二氟吡啶 合成 |
| 文章编号： | 1009-9212（2007）02-0020-02 |
| 修稿时间： | 2006-12-28 |
Synthesis of 4-Amino-3,5-dichloro-2,6-difluoropyridine |
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| YANG Jian-bo,PANG Huai-lin,HUANG Chao-qun,Tao Xian-jian.Synthesis of 4-Amino-3,5-dichloro-2,6-difluoropyridine[J].Fine Chemical Intermediates,2007,37(2):20-21. |
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| Authors: | YANG Jian-bo PANG Huai-lin HUANG Chao-qun Tao Xian-jian |
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| Affiliation: | Hunan Research Institute of Chemical Industry, Changsha 410007, China |
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| Abstract: | 4-Amino-3,5-dichloro-2,6-difluoropyridine,an important intermediate of fluroxypyr,was synthesized from 3,5-dichloro-2,4,6-trifluoropyridine(TFP)via reaction of amination using water as the solvent and under the pressure. The optimum reaction conditions were abtained as follows. Temperature was 80℃,reaction time was 30min,the molar ratio of TFP and aqueous ammonia was 1 ∶ 3.5,the catalyst (benzyl triethyl ammonium chloride)amount was 5% comparing to TFP(m/m). The yield and purith was 83.5% and over 98.6%,respeetively. The product was confirmed by IR、elementary and 1H NMR. |
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| Keywords: | 3 5-dichloro-2 4 6-trifluoropyridine amination 4-amino-3 5-dichloro-2 6-difluoropyridine synthesis |
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