| 井冈霉素载药二氧化硅空心微球的原位制备及缓释性能评价 |
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| 引用本文： | 梁旭东,李雪光,付瑶,文利雄,陈建峰.井冈霉素载药二氧化硅空心微球的原位制备及缓释性能评价[J].过程工程学报,2008,8(3):595-598. |
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| 作者姓名： | 梁旭东 李雪光 付瑶 文利雄 陈建峰 |
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| 作者单位： | 北京化工大学纳米材料重点实验室 北京化工大学纳米材料重点实验室 北京化工大学纳米材料重点实验室 北京化工大学纳米材料先进制备技术与应用科学教育部重点实验室 北京化工大学纳米材料先进制备技术与应用科学教育部重点实验室 |
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| 基金项目： | 国家自然科学基金
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教育部跨世纪优秀人才培养计划
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北京市教委资助项目 |
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| 摘 要： | 利用正硅酸乙酯在W/O乳液中的原位水解聚合，成功制备了包埋井冈霉素的二氧化硅载药空心微球. 对所得产品进行了SEM, XRD, FT-IR和粒径分布等分析，结果表明，载药空心微球粒径分布窄，范围在7.5~15 mm，球状形貌良好，具有空心结构，呈无定型态. 热重分析表明载药空心微球的药物负载量约为31.9%(w)，缓释溶出实验显示载药空心微球药物释放持续时间约240 min，最终释放量达总载药量的90%以上.
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| 关 键 词： | 空心微球 原位制备 井冈霉素 缓释 二氧化硅 |
| 文章编号： | 1009-606X(2008)03-0595-04 |
| 收稿时间： | 2008-1-22 |
| 修稿时间： | 2008年1月22日 |
In situ Preparation and Drug Release Properties of Validamycin-loaded Silica Hollow Microcapsules |
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| LIANG Xu-dong,LI Xue-guang,FU Yao,WEN Li-xiong,CHEN Jian-feng.In situ Preparation and Drug Release Properties of Validamycin-loaded Silica Hollow Microcapsules[J].Chinese Journal of Process Engineering,2008,8(3):595-598. |
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| Authors: | LIANG Xu-dong LI Xue-guang FU Yao WEN Li-xiong CHEN Jian-feng |
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| Affiliation: | Key Lab for Nanomaterials, Ministry of Education， Beijing University of Chemical Technology Key Lab for Nanomaterials, Ministry of Education， Beijing University of Chemical Technology Key Lab for Nanomaterials, Ministry of Education， Beijing University of Chemical Technology Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology Key Lab for Nanomaterials, Ministry of Education,Beijing University of Chemical Technology |
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| Abstract: | Validamycin-loaded silica hollow microspheres were prepared by in situ hydrolysis of tetraethyl orthosilicate (TEOS) in Water-Oil (W/O) emulsions. The microspheres were characterized by SEM, XRD, FT-IR and particle size distribution. The results indicated that the drug-loaded microspheres had an amorphous hollow spherical structure with the diameters of 7.5~15 mm. The amount of validamycin entrapped in the microspheres was about 31.9%(w). Sustained-releasing studies showed that the release time was about 240 min and more than 90% of the loaded drug in the microspheres was delivered, indicating good sustained release behavior of the drug-loaded microspheres. |
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| Keywords: | hollow microcapsules in situ preparation validamycin sustained release silica |
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