Performance of calcium deficient hydroxyapatite–polyglycolic acid composites: an in vitro study |
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Authors: | Nicholas Dunne Valerie Jack Rochelle O’Hara David Farrar Fraser Buchanan |
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Affiliation: | (1) School of Mechanical and Aerospace Engineering, Queen’s University of Belfast, Ashby Building, Stranmillis Road, Belfast, BT9 5AH, UK;(2) Smith & Nephew Research Centre, York, UK |
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Abstract: | The strategic incorporation of bioresorbable polymeric additives to calcium-deficient hydroxyapatite cement may provide short-term
structural reinforcement and modify the modulus to closer match bone. The longer-term resorption properties may also be improved,
creating pathways for bone in-growth. The aim of this study was to investigate the resorption process of a calcium phosphate
cement system containing either in polyglycolic acid tri-methylene carbonate particles or polyglycolic acid fibres. This was
achieved by in vitro aging in physiological conditions (phosphate buffered solution at 37°C) over 12 weeks. The unreinforced
CPC exhibited an increase in compressive strength at 12 weeks, however catastrophic failure was observed above a critical
loading. The fracture behaviour of cement was improved by the incorporation of PGA fibres; the cement retained its cohesive
structure after critical loading. Gravimetric analysis and scanning electron microscopy showed a large proportion of the fibres
had resorbed after 12 weeks allowing for the increased cement porosity, which could facilitate cell infiltration and faster
integration of natural bone. Incorporating the particulate additives in the cement did not provide any mechanism for mechanical
property augmentation or did not demonstrate any appreciable level of resorption after 12 weeks. |
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