Novel approach to control sulfamethazine misuse in food-producing animals by hair analysis |
| |
Authors: | M. Gratac s-Cubarsí M. Castellari A. Valero I. Diaz J. A. Garcí a-Regueiro |
| |
Affiliation: | a IRTA-CTC, Girona, Spain |
| |
Abstract: | The presence of sulfamethazine residues in pig and calf hair was compared with the residual levels encountered in the corresponding edible tissues (liver and muscle) as a consequence of drug administration. Sulfamethazine up to 84.7 mg kg-1 was found in calf hair samples after a pharmacological treatment, with a significant effect of hair pigmentation. High concentrations of the parent drug were detected in calf hair for 4 weeks after administration, when sulfamethazine residues were no longer detectable in the corresponding edible tissues. In a similar way, pig hair also accumulated sulfamethazine residues up to 40.5 mg kg-1, which was more than the amount detected in the corresponding muscle and liver samples at slaughter. Hair analysis seems a suitable tool to improve the efficacy of regulatory controls, and thus the safety of the food chain and to discourage the improper use of sulfamethazine in animal farming. |
| |
Keywords: | Hair analysis sulfamethazine HPLC residue detection |
本文献已被 InformaWorld 等数据库收录! |