Synthesis, Characterization and Antitumour Activity of Some Butyltin(IV) Cysteaminates and N,N-Dimethylcysteaminates |
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| Authors: | Gielen M Handlir K Hollein M de Vos D |
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| Affiliation: | Departement of General and Organic Chemistry AOSC Faculty of Applied Sciences Free University of Brussels VUV Pleinlaan 2 Brussels B-1050 Belgium. |
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| Abstract: | The synthesis and characterization of four di- and tri-n-butyltin cysteaminates and N,N-dimethylcysteaminates and three protonated / quaternized derivatives are reported. They all exhibit moderate or high in vitro cytotoxic activity. Six of seven compounds presented in this work are more active than cisplatin, etoposide and 5-fluorouracil, but less active than methotrexate and doxorubicin. |
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