Integrated semiconductor optical sensors for cellular and neural imaging |
| |
Authors: | Levi Ofer Lee Thomas T Lee Meredith M Smith Stephen J Harris James S |
| |
Affiliation: | Solid State and Photonics Laboratory, Stanford University, CA 94305, USA. levi@snow.stanford.edu |
| |
Abstract: | We review integrated optical sensors for functional brain imaging, localized index-of-refraction sensing as part of a lab-on-a-chip, and in vivo continuous monitoring of tumor and cancer stem cells. We present semiconductor-based sensors and imaging systems for these applications. Measured intrinsic optical signals and tissue optics simulations indicate the need for high dynamic range and low dark-current neural sensors. Simulated and measured reflectance spectra from our guided resonance filter demonstrate the capability for index-of-refraction sensing on cellular scales, compatible with integrated biosensors. Finally, we characterized a thermally evaporated emission filter that can be used to improve sensitivity for in vivo fluorescence sensing. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|