| 2H-1,4-苯并噁嗪衍生物的合成研究 |
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| 引用本文： | 王铨,刘建宇,张月,张辉,许永男. 2H-1,4-苯并噁嗪衍生物的合成研究[J]. 辽宁化工, 2014, 0(10): 1250-1251,1259 |
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| 作者姓名： | 王铨 刘建宇 张月 张辉 许永男 |
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| 作者单位： | 沈阳药科大学基于靶点的药物设计与研究教育部重点实验室; |
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| 基金项目： | 教育部创新团队发展计划;辽宁省高校创新团队支持计划资助 |
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| 摘 要： | 2H-1,4-苯并噁嗪类化合物存在于许多天然产物中,具有广泛的生物活性,可用作高分子材料和农药、医药的中间体。笔者合成了5个2H-1,4-苯并噁嗪衍生物,其结构经1H NMR谱、MS谱等方法确证。其中N-[2-（2-苯基-3-氧代-2H-1,4-苯并噁嗪-6-基）乙基]乙酰胺（I）为未见文献报导的新化合物。
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| 关 键 词： | 2H-1,4-苯并噁嗪 N- 乙酰胺 合成 |
Synthesis of 2H-1,4-Benzoxazine Derivatives |
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| WANG Quan;LIU Jian-yu;ZHANG Yue;ZHANG Hui;XU Yong-nan. Synthesis of 2H-1,4-Benzoxazine Derivatives[J]. Liaoning Chemical Industry, 2014, 0(10): 1250-1251,1259 |
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| Authors: | WANG Quan LIU Jian-yu ZHANG Yue ZHANG Hui XU Yong-nan |
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| Affiliation: | WANG Quan;LIU Jian-yu;ZHANG Yue;ZHANG Hui;XU Yong-nan;Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University; |
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| Abstract: | The 2H-1,4-benzoxazine derivatives with a range of bioactivities can be used as intermediates of polymer, medicine and pesticide. Many natural products contain 2H-1,4-benzoxazine derivatives. In this paper, five kinds of 2H-1,4-benzoxazine derivatives were designed and synthesized, their structures were characterized by 1H-NMR and MS spectra. In which N-[2-（2-phenyl-3-oxo-2H-1,4-benzoxazine-6-yl）ethyl]ethanamide had not reported. |
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| Keywords: | 2H-1,4-benzoxazine N- ethanamide synthesis |
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