Equilibrium of taurodeoxycholate between mixed micellar and aqueous phases: Effect of amphiphile |
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Authors: | B Borgström |
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Affiliation: | (1) Department of Physiological Chemistry, University of Lund, P.O. Box 750, S-220 07 Lund, Sweden |
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Abstract: | The equilibration of taurodeoxycholate between mixed micellar and aqueous phases has been studied by equilibrium dialysis.
The presence of amphiphiles in the form of lecithin, long chain monoglyceride, and fatty acid in the bile salt solution will
greatly decrease the bile salt concentration in the aqueous (intermicellar) phase. At high amphiphile concentration relative
to bile salt, the concentration of bile salt in the aqueous phase will be below the critical micellar concentration (CMC)
of the pure bile salt solution. Under these conditions, few simple micelles will be present and no binding of bile salts to
protein takes place as indicated by experiments with colipase. The lowering of the concentration of bile salt in the aqueous
phase by the presence of amphiphile may be a physiological mechanism to regulate bile salt absorption during the digestive
phase of fat absorption. |
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