达托霉素及其衍生物生物合成的研究进展

随着高致病耐药菌的不断出现，临床上对新抗生素的需求十分迫切。达托霉素作为环脂肽类抗生素的第一个产品对耐药菌有很好的杀菌效果，且制剂用药方便，毒副作用小，被公认为病原菌最后一道防线--万古霉素的最佳替代品。本文在介绍达托霉素的理化特征和抗菌活性、合成基因簇的研究成果的基础上，重点对达托霉素及其衍生物的研究状况进行了综述，对达托霉素的生产及其衍生物的开发进行了展望：结合系统生物学为已有的达托霉素产生菌进一步进行代谢工程改造提供指导；通过合成生物学使达托霉素衍生物成为新型抗生素。

Research progress of biosynthesis of daptomycin and its derivative

With continuous appearance of highly pathogenic bacteria which are resistant to antibiotics,the need for new antibiotics becomes much pressing in clinical medicine.As the first production of cyclo-lipotpeptied antibiotics daptomycin has effective bactericidal effect to antibiotic resistant bacteria.Because of its convenience in preparation and treatment,as well as insignificant side effects,daptomycin is the perfect replacement of vancomycin recognized as the last line of defense to pathogen.On the basis of introducing physical and chemical characteristics,antimicrobial activity and research achievement of synthetic genetic cluster of daptomycin,this paper mainly summarizes research situation of daptomycin and its derivatives.And the paper also presents perspectives about production of daptomycin and development of its derivatives,including combining with system biology to provide guidance for daptomycin strains’ further metabolic engineering improvement and utilizing synthetic biology to make derivatives of daptomycin new antibiotic.