α-Tocopherol and Ascorbate Delay Oxymyoglobin and Phospholipid Oxidation In Vitro |
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| Authors: | MC YIN C FAUSTMAN JW RIESEN SN WILLIAMS |
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| Affiliation: | Authors Yin, Faustman, and Riesen are with the Dept. of Animal Science, Univ. of Connecticut, Storrs, CT 06269–4040.;Author Williams is with Hoffmann-LaRoche, Inc., Nutley, NJ. |
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| Abstract: | An oxymyoglobin liposome model was used to study the effects of α-tocopherol and/or ascorbate upon oxymyoglobin and lipid oxidation. Both oxidations were delayed (P<0.05) by increased concentrations of α-tocopherol alone and α-tocopherol/ascorbate relative to controls. The 14 μ Mα-tocopherol/140 μM ascorbate treatment resulted in greatest delay in both oxymyoglobin and lipid oxidation. Ascorbate alone delayed oxymyoglobin oxidation; effectiveness diminished as ascorbate increased. Ascorbate showed a prooxidant effect toward lipid oxidation which was unchanged in the presence of EDTA. Results support the hypothesis that α-tocopherol retards lipid oxidation directly and OxyMb oxidation indirectly. |
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| Keywords: | α-tocopherol ascorbate myoglobin phospholipid antioxidants |
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