An in vitro study of electrically active hydroxyapatite-barium titanate ceramics using Saos-2 cells |
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Authors: | Frances R Baxter Irene G Turner Christopher R Bowen Jonathan P Gittings Julian B Chaudhuri |
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Affiliation: | (1) Department of Mechanical Engineering, Centre for Orthopaedic Biomechanics, University of Bath, BA2 7AY Bath, UK;(2) Department of Chemical Engineering, Centre for Regenerative Medicine, University of Bath, BA2 7AY Bath, UK |
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Abstract: | Electrically active ceramics are of interest as bone graft substitute materials. This study investigated the ferroelectric
properties of hydroxyapatite-barium titanate (HABT) composites and the behaviour of osteoblast-like cells seeded on their
surfaces. A piezoelectric coefficient (d33) of 57.8 pCN−1 was observed in HABT discs prepared for cell culture. The attachment, proliferation, viability, morphology and metabolic
activity of cells cultured on unpoled HABT were comparable to those observed on commercially available hydroxyapatite at all
time points. No indication of the cytotoxicity of HABT was detected. At one day after seeding, cell attachment was modified
on both the positive and negative surfaces of poled HABT. After longer incubations, all parameters observed were comparable
on poled and unpoled ceramics. The results indicate that HABT ceramics are biocompatible in the short term in vitro and that
further investigation of cell responses to these materials under mechanical load and at longer incubation times is warranted. |
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