A polymer-based spiky microelectrode array for electrocorticography |
| |
Authors: | Gergely Márton Marcell Kiss Gábor Orbán Anita Pongrácz István Ulbert |
| |
Affiliation: | 1.Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences,Hungarian Academy of Sciences,Budapest,Hungary;2.Department of Microtechnology, Institute for Technical Physics and Materials Science, Research Centre for Natural Sciences,Hungarian Academy of Sciences,Budapest,Hungary;3.School of Ph.D. Studies,Semmelweis University,Budapest,Hungary;4.Faculty of Information Technology and Bionics,Pázmány Péter Catholic University,Budapest,Hungary |
| |
Abstract: | The advanced technology of microelectromechanical systems (MEMS) makes possible precise and reproducible construction of various microelectrode arrays (MEAs) with patterns of high spatial density. Polymer-based MEMS devices are gaining increasing attention in the field of electrophysiology, since they can be used to form flexible, yet reliable electrical interfaces with the central and the peripheral nervous system. In this paper we present a novel MEA, designed for obtaining neural signals, with a polyimide (PI)—platinum (Pt)—SU-8 layer structure. Electrodes with special, arrow-like shapes were formed in a single row, enabling slight penetration into the tissue. The applied process flow allowed reproducible batch fabrication of the devices with high yield. In vitro characterization of the electrode arrays was performed with electrochemical impedance spectroscopy in lactated Ringer’s solution. Functional tests were carried out by performing acute recordings on rat neocortex. The devices have proven to be convenient tools for acute in vivo electrocorticography. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|