Diversity and complexity of ceramide signalling in apoptosis |
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| Authors: | T Okazaki T Kondo T Kitano M Tashima |
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| Affiliation: | Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Japan. toshiroo@kuhp.kyoto-u.ac.jp |
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| Abstract: | Sphingolipid ceramide has emerged as a lipid messenger of cell functions including differentiation and apoptosis. Diverse kinds of stresses (ultraviolet, irradiation, heat shock and hypoxia) and biological factors (TNF-alpha, IFN-gamma and Fas antibody) require ceramide generation to execute apoptosis. The review summarises the diversity and complexity of up- and downstream of ceramide signalling in apoptosis and clinical implications of ceramide-induced apoptosis. |
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