| Preparation and preclinical studies of a hepatic receptor imaging agent |
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| 作者姓名： | ZhangRong－Jun JinJian |
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| 作者单位： | [1]StateKeyLaboratoryofNuclearMedicine,JiangsuInstituteofNuclearMedicine,Wuxi214063 [2]StateKeyLaboratoryof,JiangsuInstituteofNuclearMedicine,Wuxi214063 |
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| 摘 要： | Galactosyl neoglycoalbumin(NGA) was synthesized by the covalent coupling of a bifunctional reagent ,2-imino-2-ethyloxymethy1-1-thiogalactose,to human serum albumin.The average number of galactose groups per albumin molecule(Gal/HSA) of NGA was 30.NGA was labeled directly with Na^99mTcO4.The radiochemical purity of ^99mTc-NGA was over 90%.Consequences of the preclinical studies show that ^99mTc-NGA is a good hepatic receptor imaging agent,uptaken by hepatic cells specifically,and excreted majorly from the biliary system and the gastrointestinal(GI) tract.
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| 关 键 词： | 肝 造影 临床前研究 |
Preparation and preclinical studies of a hepatic receptor imaging agent |
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| Zhang Rong Jun,Jin Jian,Liang Gao Lin,Wan Wei Xing,Tao Yong Hui and Wang Bo Cheng.Preparation and preclinical studies of a hepatic receptor imaging agent[J].Nuclear Science and Techniques,1998,9(3):189-192. |
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| Authors: | Zhang Rong Jun Jin Jian Liang Gao Lin Wan Wei Xing Tao Yong Hui and Wang Bo Cheng |
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| Abstract: | Galactosyl neoglycoalbumin (NGA) was synthesized by the covalent coupling of a bifunctional reagent, 2 imino 2 ethyloxymethy1 1 thiogalactose, to human serum albumin. The average number of galactose groups per albumin molecule (Gal/HSA) of NGA was 30. NGA was labeled directly with Na 99m TcO 4. The radiochemical purity of 99m Tc NGA was over 90%. Consequences of the preclinical studies show that 99m Tc NGA is a good hepatic receptor imaging agent, uptaken by hepatic cells specifically, and excreted majorly from the biliary system and the gastrointestinal (GI) tract. |
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| Keywords: | m Tc NGA Hepatic receptor imaging agent Bifunctional reagent Glycoprotein |
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