Effect of egg consumption on inflammatory markers: a systematic review and meta-analysis of randomized controlled clinical trials |
| |
| Authors: | Zohreh Sajadi Hezaveh Masoumeh Khalighi Sikaroudi Mohammadreza Vafa Zachary Stephen Clayton Sepideh Soltani |
| |
| Affiliation: | 1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;2. Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA;3. Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
| |
| Abstract: | There is little evidence about whether eggs affect inflammation. The aim of this meta-analysis was to explore the effects of egg consumption on inflammation. A systematic search of online databases (Institute for Scientific Information (ISI), Scopus, Ovid, PubMed, Cochrane) was used to gather clinical trials that assessed the effect of egg consumption on circulating inflammatory biomarkers. Using a random-effects model, pooled weighted mean differences (WMD) and corresponding standard deviations (SD) were calculated. Of the 21 eligible studies found, nine trials were eligible for analysis. Eight trials assessed high-sensitivity C-reactive protein (hs-CRP), four trials assessed interleukin-6 (IL-6), and five trials assessed tumor necrosis factor-alpha (TNF-α). Egg consumption did not affect hs-CRP (WMD 0.24 mg/L; 95% CI: -0.43, 0.90; I2 = 53.8; P = 0.48), IL-6 (WMD 0.20 pg/mL; 95% CI: -0.71, 1.11; I2 = 69.3; P = 0.50), and TNF-α (WMD: -0.38 pg/mL; 95% CI: -0.87, 0.10; I2 = 0.00; P = 0.12) relative to controls. Overall, this meta-analysis revealed that egg consumption had no significant effect on serum biomarkers of inflammation in adults. © 2019 Society of Chemical Industry |
| |
| Keywords: | Egg Inflammation Meta-analysis Systematic review Randomized controlled trial |
|
|
