Knowledge‐Based Conceptual Synthesis of Industrial‐Scale Downstream Processes for Biochemical Products |
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| Authors: | Karin Backhaus Mirka Lochmüller Markus Christian Arndt Ole Riechert Gerhard Schembecker |
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| Affiliation: | 1. TU Dortmund University, Department of Biochemical and Chemical Engineering, Laboratory of Plant and Process Design, Dortmund, Germany.;2. TU Dortmund University, Department of Biochemical and Chemical Engineering, Laboratory of Thermodynamics, Dortmund, Germany. |
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| Abstract: | A generic, knowledge‐based guideline assisting downstream process synthesis for biochemical products is presented. It offers process designers a structured process design methodology supporting them in capturing potentially relevant information, which might be beyond their expertise. The guideline is based on heuristic knowledge which was collected, structured in a generic way, and clearly represented. The generation of alternative downstream routes as starting points for experiments, simulation, and cost calculation is hereby accelerated. The application of the guideline is demonstrated on the example of penicillin V downstream processing from fermentation broth. |
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| Keywords: | Biochemical products Conceptual process synthesis Downstream processing Knowledge‐based approach |
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