| (3R,4R)-3-[(1′R)-叔丁基二甲基硅氧乙基]-4-乙酰氧基-2-氮杂环丁酮的合成 |
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| 引用本文： | 宋伟国,夏艳,高东升,宋成刚.(3R,4R)-3-[(1′R)-叔丁基二甲基硅氧乙基]-4-乙酰氧基-2-氮杂环丁酮的合成[J].山东化工,2009,38(5). |
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| 作者姓名： | 宋伟国 夏艳 高东升 宋成刚 |
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| 作者单位： | 山东寿光富康制药有限公司,山东,寿光,262700 |
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| 摘 要： | 以化合物(3S,4S)-3-(1′R)-叔丁基二甲基硅氧乙基]-4-羧基-1-对甲氧基苯基-2-氮杂环丁酮为主要原料,以卟啉锰为催化剂,经氧化脱羧,再由O3氧化脱保护基制得(3R,4R)-3-(1′R)-叔丁基二甲基硅氧乙基]-4-乙酰氧基-2-氮杂环丁酮(4AA),两步反应总收率达到83.7%.采用卟啉锰做催化剂进行脱羧氧化反应,使该步反应收率达到了93.0%.用FT-IR、1HNMR对最终产物结构进行了表征.
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| 关 键 词： | 氮杂环丁酮 卟啉锰 培南 |
Synthesis of (3R,4R)-4-Acetoxy-3-[(1'R-tert-butyl-dimethylsilyloxy)-ethyl]-2-azetidinone |
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| SONG Wei-guo,XIA Yan,GAO Dong-sheng,SONG Cheng-gang.Synthesis of (3R,4R)-4-Acetoxy-3-[(1'R-tert-butyl-dimethylsilyloxy)-ethyl]-2-azetidinone[J].Shandong Chemical Industry,2009,38(5). |
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| Authors: | SONG Wei-guo XIA Yan GAO Dong-sheng SONG Cheng-gang |
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| Affiliation: | Shandong Shouguang Fukang Pharmaceutical Co.;Ltd.;Shouguang 262700;China |
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| Abstract: | (3R,4R)-4-acetoxy-3-(1'R-tert-butyl-dimethylsilyloxy)-ethyl]-2-azetidinone (4AA) was prepared from (3S,4S)-4-carboxyl-3-(1'R-tert-butyl-dimethylsilyloxy)-ethyl]-1-p-methoxyphenyl-2-azetidinone through two-step process,involving the decarboxylation oxidation reaction which was catalyzed by manganese porphyrin and oxidized,and the reaction of oxidation using O3. The total yield of the reaction reached 83.7%. The use of manganese porphyrin catalyst raised the yield of this step to 93.0%.The product was chara... |
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| Keywords: | 4AA |
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