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| 2-取代咪唑合成方法的研究 | |
| 引用本文： | 凌勇,谢斌,肖幼安,李玉琴,黄金华,王新杨. 2-取代咪唑合成方法的研究[J]. 精细化工中间体, 2011, 41(6): 28-30,43 |
| 作者姓名： | 凌勇 谢斌 肖幼安 李玉琴 黄金华 王新杨 |
| 作者单位： | 1. 南通大学医学院,江苏南通,226001 2. 江苏万高药业有限公司,江苏南通,226100 3. 安徽中医学院药学院,安徽合肥,230031 |
| 基金项目： | 江苏省自然科学基金资助项目(BK2011389);江苏省高校优势学科建设工程支助;南通大学引进人才科研启动基金项目;2011年南通大学“大学生实践创新训练计划”项目 |
| 摘 要： | 以咪唑为起始原料,经二甲胺基磺酰氯保护,在正丁基锂条件下,分别与各种亲电试剂反应得到1-(二甲胺基磺酰基)-2-取代-咪唑,最后在稀盐酸条件下脱保护合成了一系列2-取代咪唑衍生物,其结构经1H NMR、MS和元素分析表征。 |
| 关 键 词： | 2-取代咪唑 正丁基锂 亲电试剂 |
General Synthesis of 2-Substituted Imidazoles |
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| LING Yong , XIE Bin , XIAO You-an , LI Yu-qin , HUANG Jin-hua , WANG Xin-yang. General Synthesis of 2-Substituted Imidazoles[J]. Fine Chemical Intermediates, 2011, 41(6): 28-30,43 | |
| Authors: | LING Yong XIE Bin XIAO You-an LI Yu-qin HUANG Jin-hua WANG Xin-yang |
| Affiliation: | 1(1.Medical College,Nantong University,Nantong 226001,China;2.Jiangsu Vanguard Pharmaceutical Co.,Ltd.,Nantong 226100,China;3.Anhui College of Traditional Chinese Medicine,Hefei 230031,China) |
| Abstract: | A series of 2-substituted imidazoles were synthesized from imidazole which was first protected with N,N-dimethylsulfonyl chloride,and then reacted with different electrophilic reagents under the catalysis of n-butyl lithium,followed by detach of the protection group in dilute hydrochloric acid.The structures were characterized with 1H NMR,MS and elemental analysis. |
| Keywords: | 2-substituted imidazole n-butyllithium electrophilic reagent |
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