| 瓜胶及其衍生物在药物控制释放领域的研究进展 |
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| 引用本文： | 李秀瑜,吴文辉.瓜胶及其衍生物在药物控制释放领域的研究进展[J].现代化工,2007,27(1):23-26. |
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| 作者姓名： | 李秀瑜 吴文辉 |
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| 作者单位： | 1. 河北师范大学实验中心,河北,石家庄,050016
2. 北京理工大学材料科学与工程学院,北京,100081 |
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| 摘 要： | 介绍了官能团衍生化、接枝共聚、交联等瓜胶衍生物的制备方法及影响因素、瓜胶及其衍生物在药物控制释放领域的应用现状,并指出改性瓜胶具有比原粉更好的药物控制释放效果,因此经过配方设计,瓜胶及其衍生物有望成为药物控制释放尤其是靶向结肠给药领域的理想载体。
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| 关 键 词： | 瓜胶 瓜胶衍生物 制备 药物载体 控制释放 |
| 文章编号： | 0253-4320(2007)01-0023-04 |
| 修稿时间： | 2006年10月13 |
Research progress in guar gum and its derivatives for controlled drug delivery system |
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| LI Xiu-yu,WU Wen-hui.Research progress in guar gum and its derivatives for controlled drug delivery system[J].Modern Chemical Industry,2007,27(1):23-26. |
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| Authors: | LI Xiu-yu WU Wen-hui |
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| Abstract: | The chemical modifications of guar gum(GG) including functional group derivatization,graft copolymerization and crosslinking etc.,the influences,the application of guar gum and its derivatives in the controlled drug delivery system are introduced.The GG derivatives which have better effect than that of GG powder on the controlling and releasing drug are investigated,so they can be expected to be good candidates for carriers of controlled drug delivery system,especially of the colon-specific drug delivery system after design of formular. |
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| Keywords: | guar gum guar gum derivatives preparation drug carrier controlled release |
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