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Display of the antigenic region of Nipah virus nucleocapsid protein on hepatitis B virus capsid |
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| Authors: | Yap Wei Boon Tey Beng Ti Alitheen Noorjahan Banu Mohamed Tan Wen Siang |
| Affiliation: | Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. |
| Abstract: | The C-terminal domain of Nipah virus (NiV) nucleocapsid protein (NP401–532) was inserted at the N-terminus and the immunodominant loop of hepatitis B core antigen (HBc). The stability of NP401–532 increased tremendously when displayed on the HBc particles. These particles reacted specifically with the swine anti-NiV and the human anti-HBc antisera. |
| Keywords: | Nipah virus Nucleocapsid protein Hepatitis B virus Hepatitis B core antigen Virus-like particles |
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