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Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae |
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| Authors: | Ida Yoshihiro Furusawa Chikara Hirasawa Takashi Shimizu Hiroshi |
| Affiliation: | Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita, Osaka 565-0871, Japan. |
| Abstract: | We analyzed the effects of the deletions of genes encoding alcohol dehydrogenase (ADH) isozymes of Saccharomyces cerevisiae. The decrease in ethanol production by ADH1 deletion alone could be partially compensated by the upregulation of other isozyme genes, while the deletion of all known ADH isozyme genes stably disrupted ethanol production. |
| Keywords: | Saccharomyces cerevisiae Ethanol production Alcohol dehydrogenase isozymes Gene disruption Continuous culture |
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