Inhibition of fat cell lipolysis by low FFA to albumin ratios |
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Authors: | R W Hubbard W T Matthew |
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Affiliation: | (1) Biochemistry and Pharmacology Laboratory, U.S. Army Research Institute of Environmental Medicine, 01760 Natick, Massachusetts |
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Abstract: | Epididymal fat cells isolated from chronically cold-exposed rats were used to study the inhibition of lipolysis with albumin
bound FFA. It was demonstrated that lipolysis becomes inhibited as the class 2 binding sites on albumin are filled and that
50% inhibition occurs at free fatty acid (FFA) to albumin ratios
between 4.6 and 4.0. Experiments with dibutyryl adenosine cyclic phosphate suggest that this is an effect on the fat cell
lipases rather than the lipase activating system or phosphodiesterase. The results indicate that reesterification proceeds
as a relatively constant percentage of the rate of lipolysis and, therefore, in the absence of exogenous FFA, conditions that
reduce lipolysis reduce reesterification. On the other hand, high rates of reesterification can apparently be stimulated even
when the class 1 binding sites on albumin are not filled. |
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