| 3,5-二甲基-4-羟基苯甲腈的合成研究 |
| |
| 引用本文： | 郑土才,吾国强. 3,5-二甲基-4-羟基苯甲腈的合成研究[J]. 现代化工, 2010, 30(3) |
| |
| 作者姓名： | 郑土才 吾国强 |
| |
| 作者单位： | 浙江工业大学浙西分校化学与制药工程系,浙江,衢州,324000 |
| |
| 基金项目： | 浙江工业大学浙西分校科研启动经费资助项目 |
| |
| 摘 要： | 以3,5-二甲基-4-羟基苯甲醛和盐酸羟胺为原料,分别在甲酸、乙酸和N,N-二甲基甲酰胺(DMF)中一步反应合成了3,5-二甲基-4-羟基苯甲腈。以DMF为溶剂的反应效果最好,最佳条件下收率达90%以上,粗品含量98%以上。
|
| 关 键 词： | 3,5-二甲基-4-羟基苯甲醛 3,5-二甲基-4-羟基苯甲腈 盐酸羟胺 N,N-二甲基甲酰胺 合成 |
A study on synthesis of 3,5-dimethyl-4-hydroxybenzonitrile |
| |
| ZHENG Tu-cai,WU Guo-qiang. A study on synthesis of 3,5-dimethyl-4-hydroxybenzonitrile[J]. Modern Chemical Industry, 2010, 30(3) |
| |
| Authors: | ZHENG Tu-cai WU Guo-qiang |
| |
| Abstract: | A one-pot synthesis of 3,5-dimethyl-4-hydroxybenzonitrile from 3,5-dimethyl-4-hydroxybenzaldehyde and hydroxyamine hydrochloride in solvents such as formic acid,acetic acid,and N,N-dimethylformamide (DMF) is studied.The yields are optimal if in DMF,and the optimization of reaction conditions is carried out.Under such optimum conditions the yield of the nitrile can be 93%,with purity of above 98%,which are determined by HPLC. |
| |
| Keywords: | 3,5-dimethyl-4-hydroxybenzaldehyde 3,5-dimethyl-4-hydroxybenzonitrile hydroxyamine hydrochloride N,N-dimethylformamide synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
