| 环孢菌素A与4-苯甲酰苯甲酸反应的研究 |
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| 引用本文： | 戴晓雁,刘一超,黄文才,范昕建,陈米娜,冯萍. 环孢菌素A与4-苯甲酰苯甲酸反应的研究[J]. 精细化工, 2001, 18(3): 135-137 |
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| 作者姓名： | 戴晓雁 刘一超 黄文才 范昕建 陈米娜 冯萍 |
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| 作者单位： | 1. 四川大学 化工学院,
2. 华西医科大学附属第一医院 传染病教研室, |
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| 基金项目： | 四川省重点科学技术资助项目!(970 12 15 2 5 0 1)&& |
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| 摘 要： | 从合成环孢菌素A (CsA)免疫抗原的目的出发 ,研究了CsA与 4 苯甲酰苯甲酸 (BBa)在紫外光激发下的光化学反应。确定出最佳反应条件为 :n (CsA)∶n (BBa) =1∶1,光照距离为 9cm ,光照时间为 4h。产物CsA -BBa的收率达 5 1.9% ,其结构经UV、IR和HNMR谱的证实 ,可用于免疫抗原合成及抗体制备实验。
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| 关 键 词： | 环孢菌素A 4-苯甲酰苯甲酸 光化学反应 |
| 文章编号： | 1003-5214(2001)03-0135-03 |
Study of the Reaction Between Cyclosporine A and 4-Benzoylbenzoic Acid |
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| DAI Xiao-yan,LIU Yi-chao,HUANG Wen-cai,FAN Xin-jian,CHEN Mi-la,FENG Ping. Study of the Reaction Between Cyclosporine A and 4-Benzoylbenzoic Acid[J]. Fine Chemicals, 2001, 18(3): 135-137 |
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| Authors: | DAI Xiao-yan LIU Yi-chao HUANG Wen-cai FAN Xin-jian CHEN Mi-la FENG Ping |
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| Affiliation: | DAI Xiao yan 1,LIU Yi chao 1,HUANG Wen cai 1,FAN Xin jian 2,CHEN Mi la 2,FENG Ping 2 |
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| Abstract: | To synthesize cyclosporine A(CsA) immunogen,the authors studied the reaction between CsA and 4-benzoylbenzoic acid(BBa) under the ultraviolet radiation.The optimum conditions of the reaction were n(CsA)∶n(BBa)=1∶1,irradiation distance 9 cm and irradiation time 4 h.The yield of CsA-BBa conjugate was 51.9% and its constitution was confirmed by UV,IR and HNMR.It could be used for the synthesis of CsA immunogen and the preparation of anti-CsA antibody. |
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| Keywords: | cyclosporine A 4-benzoylbenzoic acid photochemical reaction |
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