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| HP-β-CD对依达拉奉的增溶研究 | |
| 引用本文： | 刘新凯,李希美,赵兵兵,王世兵.HP-β-CD对依达拉奉的增溶研究[J].广东化工,2012,39(14):57-58. |
| 作者姓名： | 刘新凯 李希美 赵兵兵 王世兵 |
| 作者单位： | 1. 河南天方药业股份有限公司,河南驻马店,463000 2. 黄淮学院,河南驻马店,463000 3. 河南天方药业股份有限公司,河南驻马店463000／黄淮学院,河南驻马店463000 |
| 摘 要： | 采用相溶解度法探讨羟丙基-β-环糊精(HP-β-CD)对依达拉奉的增溶作用。在水溶液中,依达拉奉的浓度随HP-β-CD浓度的增加而呈线性增加,相溶解度曲线为AL型。经HP-β-CD包合后依达拉奉在水中的溶解度最高可达包合前的5.026倍,包合物的稳定常数Kc=10.31。 |
| 关 键 词： | 羟丙基-β-环糊精 依达拉奉 相溶解度法 |
Hydroxypropyl-cyclodextrin Improves the Solubility of Edarvone by Phase-solubility Method |
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| Liu Xinkai,Li Ximei,Zhao Bingbing,Wang Shibing.Hydroxypropyl-cyclodextrin Improves the Solubility of Edarvone by Phase-solubility Method[J].Guangdong Chemical Industry,2012,39(14):57-58. | |
| Authors: | Liu Xinkai Li Ximei Zhao Bingbing Wang Shibing |
| Affiliation: | 1. Henan Topfond Phamaceutical Co., Ltd., Zhumadian 463000; 2. Huanghuai University, Zhumadian 463000, China) |
| Abstract: | The enhancing effect of Hydroxypropyl-β-cyclodextrin （HP-β-CD） on the solubility of edaravone was investigated by the phase-solubility method. The solubility of edaravone increased linearly with the increase of HP-β-CD concentration in aqueous solutions, which showed typical AL-type phase solubility profile. With the complexation of edaravone and HP-β-CD, the solubility of edaravone in water increased 5.026 times of that of edaravone without HP-β-CD and the K of the inclusion complex formation constants is 10.31. |
| Keywords: | hydroxypropyl-β-cyclodextrin edaravone phase-solubility |
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