静电纺丝制备聚己内酯血管支架及其性能

采用聚己内酯(PCL)为纺丝原料,利用自制的静电纺丝设备制备了人工血管支架.研究了溶液浓度对血管支架的微观形貌、纤维直径及分布、力学性能、孔隙率以及接触角的影响.研究结果表明,在温度为30℃、相对湿度50%、纺丝电压22.5 kV,接收距离17.5 cm、二氯甲烷与N,N– 二甲基甲酰胺体积比为7:3的纺丝条件下,PCL溶液浓度为0.2 g/mL时,其力学性能和孔隙率最佳,轴向拉伸强度为(4.35±0.05)MPa,径向拉伸强度为(4.66±0.07)MPa,轴向拉伸弹性模量为(23.70±0.01)MPa,孔隙率为(74.4±0.1)%,而接触角为105.6°,纤维直径为(509.9±68.3)nm,提高了血管支架的力学性能和孔隙率.通过冷等离子体处理120 s,最终得到轴向拉伸强度为(4.10±0.05)MPa,径向拉伸强度为(4.39±0.05)MPa,轴向拉伸弹性模量为(21.20±0.15)MPa,孔隙率为(74.6±0.2)%,接触角为(60.7±2.3)° 的PCL血管支架,处理后的力学性能未发生大幅度下降,孔隙率基本没有变化,提高了支架的亲水性.

Preparation and Properties of Polycaprolactone Vascular Stent by Electrospinning

An artificial blood vessel stent was prepared by using a self-made electrospinning machine with polycaprolactone (PCL) as a spinning raw material. The effects of solution concentration on the microscopic morphology,fiber diameter and distribution, mechanical properties,porosity and contact angle of vascular stents were studied. The results show that under the spinning conditions of temperature 30℃,relative humidity 50%,spinning voltage 22.5 kV,receiving distance 17.5 cm,the volume ratio of dichloromethane to N,N-dimethylformamide is 7∶3,when the PCL solution concentration is 0.20 g/mL,the mechanical properties and porosity of artificial blood vessel stent are optimal. The axial tensile strength is (4.35±0.05) MPa,the radial tensile strength is (4.66±0.07) MPa,the axial tensile elastic modulus is (23.70±0.01) MPa,the porosity is (74.4±0.1)% and the contact angle is 105.6°,the fiber diameter is (509.9±68.3) nm and the mechanical properties and porosity of the stent are improved. Through cold plasma treatment of 120 s,a PCL stent having the axial tensile strength is (4.10±0.05) MPa,the radial tensile strength is (4.39±0.05) MPa,the axial tensile elastic modulus is (21.20±0.15) MPa,the porosity is (74.6±0.2)%,the contact angle is (60.7±2.3)° was prepared,the mechanical properties do not decrease significantly,the porosity do not change substantially,and the hydrophilicity of the stent is increased .